Dr. Dayan Goodenowe

  The development of mass spectrometry-based techniques has made it possible to compare the molecules that are changed during Alzheimer's disease. A constant decrease of plasmalogens is one of the modifications shown by this research. The varieties of phospholipids present in membranes are extremely diverse, and plasmalogens constitute a component of that vast terrain. Plasmalogens account for more than 20% of all phospholipids in humans, and they are especially abundant in the nervous system. Plasmalogen levels drop by up to 40% in Alzheimer's patients. The discovery of this large decrease in plasmalogens is critical in two areas of Alzheimer's disease: early detection and therapeutic intervention. First, these plasmalogen reductions might be effective indicators for detecting the development of Alzheimer's disease. Detecting plasmalogens levels has the benefit over other detection methods in that lower plasmalogens may be observed in blood and do not require costly an...

Plasmalogens are a subset of phospholipids. They concentrate on the brain and the heart. Plasmalogens is not just traced nutrients; they make up a significant portion of the brain, accounting for up to 20% of its dry weight. Plasmalogens serve as a storage site for essential fatty acids such as oleic acid, arachidonic acid, and docosahexaenoic acid (DHA). Plasmalogens are anti-inflammatory, powerful antioxidants, a critical component of cell membranes, lipoproteins, myelin, and synaptic membranes, and a major structural component of lipoproteins, myelin, and synaptic membranes. Plasmalogen levels in the brain rise until the age of 30 to 40, then fall precipitously by 70. There are insufficient food supplies. Plasmalogens are produced by the body in cell peroxisomes, with the liver producing the vast majority. The body's ability to produce plasmalogens hamper when peroxisome function deteriorates with age, and plasmalogens are destroyed due to inflammation and oxidative stress. ...

Supplements are typically used to deliver nutrients or vitamins insufficiently provided in the food, such as the omega fatty acids in fish oil. Although plasmalogens supplements are not yet widely known boosting plasmalogen levels may be beneficial in the prevention of Alzheimer's disease (AD). Although additional research is needed to find the optimum technique to enhance plasmalogen levels, evidence concerning why and how this may function is mounting. Meanwhile, increasing the number of scallops, mussels, and other types of seafood in the diets of Alzheimer's disease patients is a low-risk, very straightforward intervention with considerable potential advantages. The Role of Plasmalogens in Alzheimer's Disease With the introduction of mass spectrometry-based techniques, it is now possible to compare the altered molecules during AD. One of these research results has been a continuous depletion of plasmalogens. The varieties of phospholipids found in membranes are extreme...